Principal Research Scientist I, siRNA Therapeutics

Company: AbbVie
Location: South San Francisco
Posted on: February 1, 2026

Job Description:

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok . Job Description We are seeking a highly motivated and collaborative scientist with a background in therapeutic siRNA to join the growing siRNA team at AbbVie. The candidate will be part of the newly formed siRNA team with a focus on progressing therapeutic siRNA pipeline progress for oncology indications. The successful candidate will be part of a growing therapeutic siRNA group working with cross-disciplinary teams internally and externally. The candidate will direct research and serve as a lead scientist on their own project and team and contribute scientific insights into multiple other projects. Responsibilities: Function as a principal investigator to advance internal siRNA technology and programs related to oncology indications Independent responsibility for project science within his/her area of expertise on one or more project teams Collaborate with therapeutic area colleagues to advance siRNA technology applied to internal programs. Direct research and mentor a group of scientists within area of expertise Optimize internal siRNA platforms for targeted functional delivery of siRNA Manage external CROs and internal resources to meet budget and timeline constraints Collaborate closely with internal colleagues to advance cross-functional collaborative experiments and projects Serve as a subject matter expert for siRNA delivery to target tissues and experimental design & execution Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific advanced or competitive threats and respond with appropriate new strategies. Clearly communicate technology achievements and needs with management and cross functional collaborators Qualifications Qualifications: BS, MS, or PhD with typically 14 years (BS), 12 years (MS), or 6 years (PhD)of related work experience in biotech or pharma Previous experience with therapeutic siRNA, siRNA antibody conjugates, and downstream assays to measure efficacy is required Previous experience managing and leading direct report scientists Deep experience in cell culture techniques and downstream assays to evaluate RNAi compounds Previous experience in animal study design and downstream assays to evaluate genetic medicines Experience with extrahepatic delivery of therapeutic siRNA is a plus Candidate will be well versed in the field of oncology with previous experience preferred Excellent communication and interpersonal skills. Listens and understands others point of view and articulates own perspective tacitly in order to clearly communicate scientific findings with key stakeholders Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible to participate in our short-term incentiveprograms. This job is eligible to participate in our long-term incentiveprogram. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission ,incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: AbbVie, Elk Grove , Principal Research Scientist I, siRNA Therapeutics, Science, Research & Development , South San Francisco, California